The yield of their composition of extracts and essential oils differs due to different methodologies. The major constituents of kernel and seed were sabi-nene, a-pinene, b-pinene, and D-limonene. Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia. 3rd ed. Nutmeg is the CEYLON MACE . Myristica fragrans seeds Rancy Ann Thomas, S Krishnakumari Abstract The curative effects of some plants for curing various human diseases could be as a result of the presence of bioactive constituents in them. or. MF reduced central dopaminergic activity but was without any effect on pentobarbitone-induced sleep. Dean VD, Cooks RG. Natural occurrence of Erdtman’s dehydrodiisoeugenol. 2007. Several neolignans isolated from the seed and mace have show. In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. Correlation of the results with literature data demonstrates that analysis of foodstuffs by MS-MS is rapid and provides detailed structural information. HSDB 1930. pericarp; Myristicaceae; surinamensin; virolane; ). Financial support from CSIR. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Seeds of M. fragrans were powdered and extracted with chloroform to obtain trimyristin, which on saponification yielded myristic acid. To directly and accurately identify Myristica fragrans and Myristica sp. Our results support the medicinal claims of nutmeg pericarp. seed essential oil on the locomotor activity of mice in a wheel cage. The structures were solved by direct methods using, by the full-matrix least-squares technique using the program, SHELXL-97. The major constituents of leaf, mace, kernel and seed of nutmeg can be utilised in the food, perfumery, aroma and pharmaceutical industries. Acta Chem Scand. Scientific Name(s): Myristica fragrans Houtt.Common Name(s): Nutmeg, mace, සාදික්කා වසාවාසි magic, muscdier, nux moschata, myristica oil, muskatbaum Use Nutmeg and mace, widely accepted as flavoring agents, have been used in higher doses for their aphrodisiac and psychoactive properties. Effect of seed size and the ratio of solvent Nutmeg Against The yield and quality of seed Nutmegâ€™s oleoresin (Myristica fragrans … nutmeg essential oil. Chuan-Rui Zhang, Ettannil Jayashree, Paramasivam Suresh Kumar and Muraleedharan G. Nair. In addition, various parts of M. fragrans have been used in folk medicine for treating several diseases. Nutmeg is the seed or ground spice of several species of the genus Myristica. Myristica fragrans Houtt., the source of very important spice ‘nutmeg’ used world over is native to India, Indonesia, Sri Lanka, South Africa and Southeast Asia. 2009. Mrs Soumini Mathew and Mrs Viji S. for NMR and mass spectral studies. Biological Effects of Myristica fragrans. Free Online Library: Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae). Display Name: Myristica fragrans, ext. Download with Google Download with Facebook. The species is dioecious, i.e. Antioxidant and antiinflammatory compounds in nutmeg (Myristica fragrans) pericarp as determined by invitro assays. Nadkarni K. 1998. NLM The aril (mace) of Myristica fragrans, known as Dok-Chan, is a spice that has long been used for treating stomach discomfort, peptic ulcer, and nausea. Download Free PDF. Structures of isolated compounds, 1.19 (d), 1.89 (dd)], four methoxy groups [, 3.82 (s), 3.85 (6H, s), 3.90 (s)], a hydroxyl group, O], ﬁve aromatic protons and two oleﬁnic protons [, integrating for one proton and a doublet of quartet at, C NMR and DEPT spectra showed the presence o, six methyl, nine methine and seven quaternary carb, 55.9 and 60.8 could be attributed to methoxy groups. Medically reviewed by Drugs.com. There were obvious differences between the FTIR spectrums of above-mentioned plants. and Myristica malabarica Lamk. Abstract. Here, preliminary phytochemical screening and total flavonoid content in extracts of seeds of Myristica fragrans and leaves of Cordyline terminalis have been investigated. Apart from these two, previously known steroids, other lignans and neolignans were isolated from the fruit pericarp of M. fragrans. 2006-06-06. Nutmeg oil. The compositions may contain, and be standardized to, myristicin and may be administered prior to physical exercise. Nutmeg mace is well known all over the world as an important spice. Constitutions of diarylpropanoids from. Structure of, determination, which also further helped to conﬁrm the stereochemistry of compounds, Figure 1. Being one of the popular spices in the culinary sector, the plant products are traditionally used in folk medicines for treating various human ailments. 55:589, Choo LC, Wong SM, Liew KY. 1999. J Agric Food Chem. You searched for: Subject "Myristica fragrans" Remove constraint Subject: "Myristica fragrans" The minimum inhibitory and minimum aflatoxin inhibitory concentrations of MFEO were 2.75 and 1.5 mg/ml, respectively. Piras A, Rosa A, Marongiu B, Atzeri A, Dessì MA, Falconieri D, Porcedda S. J Food Sci. : 3-(3, 4, 5-trimethoxyphenyl)-2-(E)-propen-1-ol (1), 3-(3-methoxy-4, 5-methylenedioxyphenyl)-2-(E)-propen-1-ol (2), 2, 3-dihydro-7-methoxy-2-(3, 4-dimethoxyphenyl)-3-methyl-5-(1-(E)-propenyl)benzofuran (3), fragransol-C (4), fragransol-D (5), 2, 3-dimethyl-1, 4-bis-(3, 4-methylenedioxyphenyl)butan-1-ol (6), myristicanol-A (7) and myristicanol-B (8). Chemical Composition, Antimicrobial and In Vitro Antioxidant Properties of Monarda citriodora var. It is a well-known aromatic perennial plant with a characteristic scent that possesses multiple medicinal applications, being used to treat stomach ulcers, indigestion, liver disorders, and as emmenagogue, nervine, diuretic, diaphoretic, and aphrodisiac. The chemical composition of nutmeg and mace of Myristica fragrans collected from Tellicherry and Kannur areas (North Kerala) was studied. From this extract, eight new neolignans, maceneolignans A-H (1-8), were isolated, and their stereostructures were elucidated from their spectroscopic values and chemical properties. Gas chromatography-mass spectrometry analysis of essential oil showed the presence of 38 components representing about 99.6% of the total weight. The major hallucinogenic principle in Indian nutmeg/mace oils appears to bemyristicin which is present in good amount. Myristica fragrans is native to the exotic Spice Islands or Maluku of Indonesia, though it now also grown in India, Malaysia, Sri Lanka, Taiwan, China, and the Caribbean region, amongst other countries. GC profiles of the oils compared very well with reports in Ii terature. Molecules. The mengkudu oil exhibited IC₅₀ values of 91.46 and 78.15 µg mL⁻¹ for HCT-116 and MCF-7, respectively. Thirteen compounds were isolated in a pure form and identified as: elemicin (1), isoelemicin (2), myristicin (4), surinamensin (5), malabaricone C (6), 2-(3'-allyl-2',6'-dimethoxy-phenyloxy)-1-acetoxy-(3,4-dimethoxyphenyl)-propyl ester (7), methoxylicarin A (8), licarin A (9), malabaricone B (10), licarin C (11), 5'-methoxylicarin B (12), licarin B (13), and 2-(3'-allyl-2',6'-dimethoxy-phenyloxy)-1-methyl-5-methoxy-1,2-dihydrobenzofuran (3, a new compound). Copyright © 2011 Society of Chemical Industry. 1986. Thirty rats (150-160g) grouped into 5 and each group contains 6 rats. Molecules. Earlier reports have attributed amphetamine-like activities to nutmeg. The effect on gross behaviour, motor coordination, haloperidol-induced catalepsy (using Bar test) and pentobarbitone-induced sleep was studied. The oil we sell the is the oil extracted from the seeds, pure nutmeg oil. Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia. Furthermore, the X-ray crystal structure of odoratisol A is reported in this paper for the first time. Piaru SP, Mahmud R, Abdul Majid AM, Ismail S, Man CN. The result of the study showed that yield was 13.6%±0.2% and 24 components were identified. Irradiation resulted in significant elevation in LPO level and ACP activity, and decreased the GSH content and ALP activity. Amin Shah. Although extensive literature exists on antioxidant properties of medicinal plants, very few studies have focused on their polyphenolic composition. 1999. CAS Number: 84082-68-8 Molecular formula: Unspecified (UVCB) (Myristicaceae), an aromatic evergreen tree, is well known as a commercial source of mace (aril) and nutmeg (seed), which have long been widely used as spices in the culinary field. The nutmeg sample is analyzed directly; no extraction, derivatization, or other sample preparation is necessary. Journal of the …, 2012. The essential oil may be recommended as plant based food preservative after large scale trials and reduction in methylglyoxal suggests its application for development of aflatoxin resistant varieties through green transgenics. Fourier transform infrare(FTIR) spectrum method was used. RESULTS: Thirty‐eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. radiation on a Bruker SMART APEX diffractometer (Bruker AXS, has been deposited with the Cambridge Crystal, are reported from this plant for the ﬁrst time. Intensity data for all the four crystals were collected usin, WI, USA) equipped with CCD area detector at 293, reduction were processed with SAINT software. Myristica fragrans (f. Myristicaceae) seeds are better known as a spice, but their chemical compounds may have a pharmacological effect. This also was used to pinpoint instances where MS-MS spectra contained contributions from more than one structural isomer. When the oil is made from the husks it produces mace. ... Chemical composition – Monoterpene hydrocarbons represent more than 80% of α-pinene of the total composition, β-pinene, α and β-terpinene, myrcene, camphene, limonene and sabinene, α and β-phellandrene, 3-carene, terpineol, α-tujene, p-cymene and 1, 4-mentadiene. Active, expires 2033-12-08 Application number US14/036,097 Other versions Constituents of Myristica fragrans (nutmeg) in the molecular weight range 100-700 amu are characterized via MS-MS (mass spectrometry-mass spectrometry). were identificated by FTIR directly, fast and accurately. Main results: GC-MS analyzes shows that γ-terpinene (19.16%), (-)-terpinen-4-ol (14.08%), α-pinene (6.75%), myristicin (6.18%), β-pinene (4.85%), sylvestrene (4.72%), elemicin (4.68%) and safrole (4.17%) identified in. To address the consistency and supply issue we utilized available technology to develop a reproducible procedure for preparation of specific extracts and isolation of the major phenolic constituents present in nutmeg kernel. The antioxidant activity was also determined. degli Studi di Cagliari, Cittadella Univ. East indian nutmeg oil. Hepatoprotective effect. Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Compositions as nutritional supplements comprising extracts of Myristica fragrans for improving exercise performance and for promoting weight loss are disclosed. Of those constituents, compounds 1, 4, 6, and 8 and (+)-erythro-(7S,8R)-Δ(8')-7-hydroxy-3,4-methylenedioxy-3',5'-dimethoxy-8-O-4'-neolignan (11), (-)-(8R)-Δ(8')-3,4-methylenedioxy-3',5'-dimethoxy-8-O-4'-neolignan (17), (+)-licarin A (20), nectandrin B (25), verrucosin (26), and myristicin (27) inhibited CCR3-mediated chemotaxis at a concentration of 1 μM. NIH The chemical constituents in Myristica fragrans seeds were ana-lyzed using proximate analysis, atomic absorption spectroscopic (AAS), phytochemical and gas chromatographic-mass spectro-metric (GC-MS) methods. But, so far, there are no reports on the identification of different flavonoid type of polyphenolic compounds from these two plants. : 3-(3, 4, 5-trimethoxyphenyl)-2-(E)-propen-1-ol (1), 3-(3-methoxy-4, 5-methylenedioxyphenyl)-2-(E)-propen-1-ol (2), 2, 3-dihydro-7-methoxy-2-(3, 4-dimethoxyphenyl)-3-methyl-5-(1-(E)-propenyl)benzofuran (3), fragransol-C (4), fragransol-D (5), 2, 3-dimethyl-1, 4-bis-(3. 830 pp. Nutmeg at high doses is considered a cheap substitute to several drugs of abuse. Myristica fragrans and Myristica sp. Only steroid-class of compounds: steroidal sapogenins, steroidal saponins and new cholestane glycosides are known from the leaves of C. terminalis , whereas lignan class of polyphenolic compounds and terpenes were identified from M. fragrans , Nutmeg, the seeds of Myritica fragrans (family Myristicaceae), is a well known kitchen spice with a long-standing reputation as a psychoactive herb. 1973. A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated from Myristica fragrans for the first time. 2010 Aug 1;75(6):C466-72. It produces two spices – mace and nutmeg. Please enable it to take advantage of the complete set of features! and Myristica malabarica Lamk. China. New constituents of the aril of, Isogai A, Murrakoshi S, Suzuki A, Tamura S. 1973. Studies on dental caries prevention by traditional medicines. The structures of the compounds were identified by employing various spectroscopic methods. are two well known tropical medicinal plants and widely used for the cure and management of many diseases and ailments. The proximate composition and mineral composition of dried Myristica fragrans (nutmeg) seeds were studied. Keywords: nutmeg's oleoresin, heating, chemical compositions, antifungal properties. Compounds were characterized by recording the mass spectrum of fragments formed by collision-induced dissociation of particular ions, often the protonated molecules. Medically reviewed by Drugs.com. Nutmeg butter oil [Oil, edible] Myrtle oil (Myrtus communis L.) Nutmeg oil (Myristica fragrans Houtt.) )-prop-1-enyl)-2-(3,4,5-tri methoxy phenyl)-2,3-dihydrobenzofuran, licarin B, http://dx.doi.org/10.1080/14786419.2014.934236, ). Influence of heating on antioxidant activity and the chemical composition of some spice essential oils . Among them, 1 (EC50 1.6 μM), 6 (1.5 μM), and 8 (1.4 μM) showed relatively strong activities, which were comparable to that of a synthetic CCR3 selective antagonist, SB328437 (0.78 μM). Essential oil of nutmeg pericarp. The wood of Virola multinervia Ducke (Myristicaceae) contains sitosterol, stigmasterol and two novel diarylpropanoids virolane [1-(2-hydroxy-4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-propane] and virolanol [2-hydroxy-1-(2-hydroxy-4-methoxyphenyl)-3-(3,4-methylenedioxyphenyl)-propane]. Nutmeg (Myristica fragrans Houtt. Group-1 was normal control and 2-5 groups were fed with cafeteria diet for 15 weeks to induce obesity. from the Western Ghats, India, Preliminary screening of potential flavonoid-subclasses in Myristica fragrans and Cordyline terminalis by LC-ESI-MS, Aromatic compounds from Endocomia macrocoma, Myristigranol, a new diarylpropane derivative from the wood of Myristica fragrans, Assessment of chemically characterised Myristica fragrans essential oil against fungi contaminating stored scented rice and its mode of action as novel aflatoxin inhibitor, Phytochemical investigation on Myristica fragrans stem bark. Central Salt and Marine Chemicals Research Institute, National Institute for Interdisciplinary Science and Technology, Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli, Compositional variation in the leaf, mace, kernel, and seed essential oil of nutmeg (Myristica fragrans Houtt.) The chemical constituents of the extracts were quantified via high performance liquid chromatography (HPLC). PDF. GC-MS Analysis of the Composition of the Extracts and Essential Oil from. 1996b;Atta-ur-Rahman et al. These results may also be useful to assess antioxidant activity of only the subclass alone and accordingly appropriate subclasses can be selected to prepare formulations having nutraceutical applications. The MTT assay of nutmeg oil on human colorectal carcinoma (HCT-116) and human breast carcinoma (MCF-7) cell lines showed IC₅₀ values of 78.61 and 66.45 µg mL⁻¹, respectively. Isolation from nutmeg of growth inhibitory substances to silkworm, Jaiswal P, Kumar P, Singh VK, Singh DK. Volatiles Profiling, Allelopathic Activity, and Antioxidant Potentiality of, A Design of Experiment Approach for Ionic Liquid-Based Extraction of Toxic Components-Minimized Essential Oil from, Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (. Different behavioral effects were observed that varied by the type of extract as well as by the route of administration. Piaru SP, Mahmud R, Abdul Majid AM, Ismail S, Man CN. The results revealed that yields of EO were 3.16%, 8.10%, 6.24%, and 5.21% for leaf, mace, kernel, and seed, respectively. INTRODUCTION Myristica fragrans is commonly known as “nutmeg”, it produces two spices: mace and nutmeg. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) The nutmeg tree (Myristica fragrans Houtt.) Myristica fragrans (fragrant nutmeg or true nutmeg) is a dark-leaved evergreen tree cultivated for two spices derived from its fruit: nutmeg, from its seed, and mace, from the seed covering.It is also a commercial source of an essential oil and nutmeg butter. 2019 Feb 7;24(3):584. doi: 10.3390/molecules24030584. Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia It produces two spices – mace and nutmeg. Cytotoxicity evaluation of the new compounds against five human tumor lines showed no inhibitory effects. Myristica fragrans (fragrant nutmeg or true nutmeg) is a dark-leaved evergreen tree cultivated for two spices derived from its fruit: nutmeg, from its seed, and mace, from the seed covering. 2000. Myristica Fragrans. Results showed the percentage prox-imate composition of M. fragrans seeds as: crude ash < … Create. © 2008-2020 ResearchGate GmbH. The rind ofthe nutmeg fruit con tain good quality pectin upto 14%. 1982. The same approach can also be adapted to other medicinal plants of potential interest. Aril and kernel of the fruit of these plants are used in several ayurvedic preparations. The haloperidol-induced catalepsy was potentiated but motor coordination and pentobarbitone-induced sleep were not affected significantly. Antimycobacterial neolignans isolated from, Morita T, Jinno K, Kawagishi H, Arimoto Y, Suganuma H, Inakuma T, Sugiyama K. 2003. It is also a unique spice, which causes hallucination if consumed in large quantities. Administration of MF significantly enhanced hepatic glutathione (GSH) and decreased testicular lipid peroxidation (LPO) level whereas acid phosphatase (ACP) and alkaline phosphatase (ALP) activity did not show any significant alteration. The analysis is facilitated by temperature profiling and by utilizing different reagent gases in the chemical ionization (CI) source of the mass spectrometer. All the compounds were identiﬁed by the comparison of their, was also conﬁrmed by single crystal X-ray structure. 2015. MF pretreatment effectively protected against radiation induced biochemical alteration as reflected by a decrease in LPO level and ACP activity, and an increase in GSH and ALP activity. PDF. Centre with deposition number CCDC 984377. these compounds were established on the basis of spectroscopic techniques and X-ray. Nutmeg, Myristica fragrans, is known for its culinary and medicinal values. Antioxidant lignans from Machilus thunbergii, -injured primary cultures of rat hepatocytes. medicinal and commercial value, the dried kernel (seed) and mace/aril are the most exploited, About 30 non-volatile compounds have been reported from seed and mace of, Whereas the essential oil of nutmeg fruit pericarp has, the non-volatile constituents from the fruit pericarp have not been studied so far. di Scienze Chimiche, Univ. Journal of the …, 2012. | - Biological Ef fects of Myristica fragrans 23. geraniol, terpineol, together 5 to 15%) and phenylpropanoids (myristicin, elemicin, safrole, eugenol. ), belonging to the family Myristicaceae, is a spice seed from the fruit of a tropical evergreen tree. Chemical Composition and Antioxidant Activity of Essential Oil and Oleoresins of Nutmeg (Myristica fragransHoutt.) Nutmeg is the The ethanol-extracted essential oil of M. fragrans showed bioactivity against adult female whiteflies, with different concentrations exerting significant activities for different durations. Seed extracts from Myristica fragrans (Nutmeg) and ... and metal‐induced oxidative damage in penile homogenate in vitro. To the best of our knowledge, this is the ﬁrst report on the isolation and identiﬁcation of, . Data were taken with both a sector type and a triple quadrupole MS-MS instrument. | The chemical composition of nutmeg and cardamom essential oil was analyzed by GC-MS. Last updated on Jul 3, 2020. 4-methylenedioxyphenyl)butan-1-ol (6), myristicanol-A (7) and myristicanol-B (8). Join ResearchGate to find the people and research you need to help your work. Myristigranol, a new diarylpropane derivative, was isolated from the methanol extract of Myristica fragrans wood along with one diarylpropanoid and three stilbenoids. The ethanol-extracted essential oil of M. fragrans showed bioactivity against adult female whiteflies, with different concentrations exerting significant activities for different durations. Myristica fragrans Houtt.